The lyase activity of the DNA repair protein β-polymerase protects from DNA-damage-induced cytotoxicity

@article{Sobol2000TheLA,
  title={The lyase activity of the DNA repair protein β-polymerase protects from DNA-damage-induced cytotoxicity},
  author={Robert W Sobol and Rajendra Prasad and Andrea J Evenski and Audrey Baker and Xiao-Ping Yang and Julie K. Horton and Samuel H. Wilson},
  journal={Nature},
  year={2000},
  volume={405},
  pages={807-810}
}
Small DNA lesions such as oxidized or alkylated bases are repaired by the base excision repair (BER) pathway1. BER includes removal of the damaged base by a lesion-specific DNA glycosylase, strand scission by apurinic/apyrimidinic endonuclease, DNA resynthesis and ligation2. BER may be further subdivided into DNA β-polymerase (β-pol)-dependent single-nucleotide repair and β-pol-dependent or -independent long patch repair subpathways3,4,5,6. Two important enzymatic steps in mammalian single… CONTINUE READING

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