The lung in rheumatoid arthritis, cause or consequence?

@article{Chatzidionisyou2016TheLI,
  title={The lung in rheumatoid arthritis, cause or consequence?},
  author={Aikaterini Chatzidionisyou and Anca Catrina},
  journal={Current Opinion in Rheumatology},
  year={2016},
  volume={28},
  pages={76–82}
}
Purpose of reviewRecent discoveries implicate the lungs as a possible extra-articular mucosal site for initiating rheumatoid arthritis-associated immunity. Recent findingsIndividuals at risk for developing arthritis and patients with early untreated rheumatoid arthritis show signs of lung involvement on high-resolution computer tomography. Rheumatoid arthritis-associated antibodies are present in patients with respiratory complains such as bronchiectasis and unexplained dyspnea even in the… 

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References

SHOWING 1-10 OF 85 REFERENCES

Rheumatoid arthritis and lung disease: from mechanisms to a practical approach.

Common scenarios facing pulmonologists and rheumatologists are addressed using the current best evidence; these include screening the new patient; monitoring and choosing RA treatment in the presence of subclinical disease; treating deteriorating ILD; and establishing a diagnosis in a patient with an acute respiratory presentation.

Brief report: airways abnormalities and rheumatoid arthritis-related autoantibodies in subjects without arthritis: early injury or initiating site of autoimmunity?

OBJECTIVE To evaluate the presence of pulmonary abnormalities in rheumatoid arthritis (RA)-related autoantibody-positive subjects without inflammatory arthritis. METHODS Forty-two subjects who did

Rheumatoid arthritis–associated autoantibodies in non–rheumatoid arthritis patients with mucosal inflammation: a case–control study

Although overall levels were low, RA-AAB seropositivity was associated with lung mucosal inflammation (BR and CF) and may be associated with oral mucosalinflammatory (PD) and precedes rheumatoid arthritis.

Lung biopsy in rheumatoid arthritis.

Five different groups based on histologic patterns were identified: pulmonary rheumatoid nodules, usual interstitial pneumonia (UIP), bronchiolitis obliterans with patchy organizing pneumonia (BOOP), lymphoid hyperplasia, and cellular interstitial infiltrates.

Clinical and laboratory factors associated with interstitial lung disease in rheumatoid arthritis

Anti-CCP antibodies and the RF may be pathogenically related to ILD, and the association between ILD and smoking is dependent on the HLA–DRB1 SE, which may reflect gene–environment interaction.

Diffuse interstitial lung disease in rheumatoid arthritis. Views on immunological and HLA findings.

The male RA patient group with DILD also included patients with other intrathoracic manifestations and had a higher prevalence of HLA-B8 and Dw3 than did healthy controls, thus agreeing with earlier results that RA patients with this antigen combination are prone to multiple intrathOracic complications.

Airways obstruction in rheumatoid arthritis.

The prevalence of airflow obstruction is remarkably high, and it is suggested that airway disease may be the commonest form of lung involvement in rheumatoid arthritis.

RA autoantibodies as predictors of rheumatoid arthritis in non-cystic fibrosis bronchiectasis patients

The relationship between bronchiectasis and RF and anti-CCP and key exclusion criteria included inflammatory arthritis, tuberculosis or other forms of lung disease, and Cystic fibrosis was excluded using genotyping and sweat testing following British Thoracic Society guidelines.

Open lung biopsy of patients with rheumatoid arthritis

The clinical data and laboratory findings for the histopathological groups overlapped and did not properly predict the anatomical picture.
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