The luminal Ca2+ transient controls Ca2+ release/re-uptake of sarcoplasmic reticulum.

@article{Ikemoto2000TheLC,
  title={The luminal Ca2+ transient controls Ca2+ release/re-uptake of sarcoplasmic reticulum.},
  author={Noriaki Ikemoto and Takuma Yamamoto},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={279 3},
  pages={858-63}
}
Our recent study (Saiki, Y., and Ikemoto, N., Biochemistry 38, 3112-3119, 1999) suggests that Ca2+ release and re-uptake of the released Ca2+ are coordinated. The following results suggest that the coordination is mediated by the luminal Ca2+ ([Ca2+]lum) transient. Upon inducing the release of the passively loaded Ca2+ from the SR with polylysine, the luminal Ca2+ ([Ca2+]lum) first increased then decreased ([Ca2+]lum transient). The activity of the SR Ca2+ ATPase was monitored at different… CONTINUE READING