The low viability of human CD34+ cells under acidic conditions is improved by exposure to thrombopoietin, stem cell factor, interleukin-3, or increased cyclic adenosine monophosphate levels.

@article{DAtri2011TheLV,
  title={The low viability of human CD34+ cells under acidic conditions is improved by exposure to thrombopoietin, stem cell factor, interleukin-3, or increased cyclic adenosine monophosphate levels.},
  author={Lina Paola D'Atri and Julia Etulain and Mar{\'i}a Albertina Romaniuk and Oscar Walter Torres and Soledad Negrotto and Mirta Schattner},
  journal={Transfusion},
  year={2011},
  volume={51 8},
  pages={1784-95}
}
BACKGROUND Transplanted hematopoietic progenitor cells (CD34+) have shown great promise in regenerative medicine. However, the therapeutic potential of transplanted cells is limited by their poor viability. It is well known that the microenvironment in which progenitors reside substantially affects their behavior. Because extracellular acidosis is a common feature of injured tissues or the tumor microenvironment and is a critical regulator of cell survival and activation, we evaluated the… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Similar Papers

Loading similar papers…