The low density lipoprotein receptor is not necessary for maintaining mouse brain polyunsaturated fatty acid concentrations.

@article{Chen2008TheLD,
  title={The low density lipoprotein receptor is not necessary for maintaining mouse brain polyunsaturated fatty acid concentrations.},
  author={Chuck Chen and David W L Ma and John Hongjip Kim and Howard T. J. Mount and Richard P. Bazinet},
  journal={Journal of lipid research},
  year={2008},
  volume={49 1},
  pages={
          147-52
        }
}
The brain cannot synthesize n-6 or n-3 PUFAs de novo and requires their transport from the blood. Two models of brain fatty acid uptake have been proposed. One requires the passive diffusion of unesterified fatty acids through endothelial cells of the blood-brain barrier, and the other requires the uptake of lipoproteins via a lipoprotein receptor on the luminal membrane of endothelial cells. This study tested whether the low density lipoprotein receptor (LDLr) is necessary for maintaining… CONTINUE READING

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