The low barrier hydrogen bond (LBHB) proposal revisited: The case of the Asp ··· His pair in serine proteases

  title={The low barrier hydrogen bond (LBHB) proposal revisited: The case of the Asp ··· His pair in serine proteases},
  author={Claudia N. Schutz and Arieh Warshel},
  journal={Proteins: Structure},
The fact that hydrogen bonds (HBs) can provide major stabilization to transition states (TSs) of enzymatic reactions is well known. However, the nature of HB stabilization has been the subject of a significant controversy. It is not entirely clear if this stabilization is associated with electrostatic effects of preorganized dipoles or with delocalized resonance effects of the so‐called low barrier hydrogen bond (LBHB). One of the best test cases for the LBHB proposal is the complex of… 
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