The low‐incidence red cell antigen Wra: genetic studies

  title={The low‐incidence red cell antigen Wra: genetic studies},
  author={Marion Lewis and Hiroko Kaita and S. Philipps and Phyllis J. Mcalpine},
Studies of 91 individuals in three families allowed a genetic‐linkage analysis of the gene governing the production of the low‐incidence red cell antigen Wra and provided evidence that Wra is not a member of the Scianna, Landsteiner‐Wiener, Chido/Rodgers, or XK blood group systems, and that the “WR” locus is excluded from autosomal sites or regions 1p34‐p22.1, 1p21‐q23, 1q32, 2p25, 3q21, 4q28‐q32, 6p24‐q12, 9q34.1‐ q34.2, 13q14.1‐q14.2, 14q24.3‐q32.1, 14q32.33, 16p13, 16q22.1, and 21q21‐q22.1… Expand
9 Citations
Linkage Relationships and Gene Mapping of Human Blood Group Loci
This chapter will detail the process and progress in blood group gene mapping and mention the associated problems that justify the Human Gene Mapping Workshop requirement that all gene assignments toExpand
Comparative Immunochemical Analysis of Wra and Wrb Red Cell Antigens
Immunoblotting and immunoprecipitation studies using monoclonal anti‐Wra and anti‐Wrb antibodies to investigate the nature of the lowincidence blood group antigen, Wra and its high‐incidence allelic antigen Wrb confirmed that the Wrb antigen involves both glycophorin A and band 3. Expand
Comparative immunochemical analysis of Wra and Wrb red cell antigens.
Immunoblotting and immunoprecipitation studies confirmed that the Wrb antigen involves both glycophorin A and band 3, and the monoclonal anti-Wra, BGU1-WR, failed to immunopRecipitate these or any othe red cell membrane component. Expand
Cost Comparison of Recombinant Human Erythropoietin and Blood Transfusion in Cancer Chemotherapy-Induced Anemia
From a healthcare system cost and outcome perspective, blood transfusion is the preferred strategy for chemotherapy-induced anemia, however, rHuEPO may be considered an effective blood-sparing alternative for patients with non-stem cell disorders. Expand
Blood Transfusion and Blood Conservation: Cost and Utilization Issues
The purpose of this review is to provide an overview of emerging data on the cost-effectiveness of blood and blood conservation interventions in order to help identify areas important for future investigation. Expand
The risk of transfusion-transmitted infection.
  • R. Dodd
  • Medicine
  • The New England journal of medicine
  • 1992
The selection of safe donors provides the greatest safety and the current detection rate for human immunodeficiency virus infection among active blood donors in the United States is between 5 and 10 confirmed positive results per 100,000. Expand
Transmission of disease through transplantation of musculoskeletal allografts.
  • W. Tomford
  • Medicine
  • The Journal of bone and joint surgery. American volume
  • 1995


Centromeric linkage in man
The aim of this work is to provide geneticists with appropriate statistical methods and computer programmes for the analysis of human pedigree data in view of mapping genes on the human chromosomes,Expand
Relative positions of chromosome 1 loci Fy, PGM1, Sc, UMPK, Rh, PGD and ENO1 in man.
  • M. Lewis, H. Kaita, B. Chown
  • Biology, Medicine
  • Canadian journal of genetics and cytology. Journal canadien de genetique et de cytologie
  • 1977
In the male no evidence of double crossing-over was found in the similar distances PGM1--Rh and Sc--PGD in 13 and 19 opportunities respectively, and indications are that this is not a rare event in the female. Expand
The chromosome 19 linkage group LDLR, C3, LW, APOC2, LU, SE in man
The data establish linkage in both sexes for LDLR:LW and APOC2:LU and for LW:APOC2, and LW:LU linkage in the male, and the loci constitute two tightly linked gene clusters distinguished by measurable linkage in female meioses within but not between clusters. Expand
Studies on the Wright Blood Group System
A severe haemolytic transfusion reaction due to Wra incompatibility is described. It was characterized by jaundice and oliguria; the latter lasted for 16 days and necessitated three courses ofExpand
Blood Groups in Man
This stimulating book on hydrogen-ion regulation and biochemistry in anaesthesia is well presented; the printing and paper are good, but the price will not encourage widespread use of the book among the younger members of the authors' specialty. Expand
Blood Group Terminology 1990
Blood group terminology
  • Vox Sang 1990,58:152-69
  • 1990
Report of the nomenclature committee and the 1989 catalog of mapped genes.
Report of the committee on linkage and gene order.
Ihe sequence of chromosome 3 1ociAHSG:TF:CHEI
  • Hum Hered
  • 1987