The loss of mdm2 induces p53 mediated apoptosis

@article{Rozieres2000TheLO,
  title={The loss of mdm2 induces p53 mediated apoptosis},
  author={Sohela de Rozieres and Ruth Maya and Moshe Oren and Guillermina Lozano},
  journal={Oncogene},
  year={2000},
  volume={19},
  pages={1691-1697}
}
The p53 tumor suppressor gene product is negatively regulated by the product of its downstream target, mdm2. The deletion of mdm2 in the mouse results in embryonic lethality at 5.5 days post coitum (d.p.c.) which can be overcome by simultaneous loss of the p53 tumor suppressor, substantiating the importance of the negative regulatory function of MDM2 on p53 function in vivo. Hence, the loss of MDM2 allowed the unregulated p53 protein to continuously exert its growth-suppressing activity, which… CONTINUE READING

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