The loss of c-Jun N-terminal protein kinase activity prevents the amyloidogenic cleavage of amyloid precursor protein and the formation of amyloid plaques in vivo.

@article{Mazzitelli2011TheLO,
  title={The loss of c-Jun N-terminal protein kinase activity prevents the amyloidogenic cleavage of amyloid precursor protein and the formation of amyloid plaques in vivo.},
  author={Sonia Mazzitelli and Ping Xu and Isidro Ferrer and Roger J Davis and Cathy Tournier},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 47},
  pages={16969-76}
}
Phosphorylation plays a central role in the dynamic regulation of the processing of the amyloid precursor protein (APP) and the production of amyloid-β (Aβ), one of the clinically most important factors that determine the onset of Alzheimer's disease (AD). This has led to the hypothesis that aberrant Aβ production associated with AD results from regulatory defects in signal transduction. However, conflicting findings have raised a debate over the identity of the signaling pathway that controls… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 4 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

Induction of GADD34 Regulates the Neurotoxicity of Amyloid β.

American journal of Alzheimer's disease and other dementias • 2015
View 8 Excerpts
Highly Influenced

Amyloid-Beta: A Crucial Factor in Alzheimer's Disease

Medical principles and practice : international journal of the Kuwait University, Health Science Centre • 2015

References

Publications referenced by this paper.
Showing 1-10 of 37 references

Mitogen-activated protein kinase kinase 4 is an essential activator of the c-Jun N-terminal protein kinase during brain development

X Wang, B Nadarajah, +5 authors C Tournier
Mol Cell Biol • 2007
View 5 Excerpts
Highly Influenced

acceptor site in the presenilin-1 gene

M Ramin, P Azizi, F Motamedi, A Haghparast, F Khodagholi
Inhi- • 2011
View 2 Excerpts

Similar Papers

Loading similar papers…