The loss of Mcl-1 expression in human polymorphonuclear leukocytes promotes apoptosis.

@article{Leuenroth2000TheLO,
  title={The loss of Mcl-1 expression in human polymorphonuclear leukocytes promotes apoptosis.},
  author={S J Leuenroth and Patricia S. Grutkoski and Alfred Ayala and H. Hank Simms},
  journal={Journal of leukocyte biology},
  year={2000},
  volume={68 1},
  pages={158-66}
}
The regulation of polymorphonuclear leukocyte (PMN) apoptosis can influence the duration of the inflammatory response. We have previously shown that PMN apoptosis is delayed by matrix adhesion and hypoxia; however, the mechanisms responsible for this delay are not well understood. Mcl-1, an antiapoptotic Bcl-2 family member, is present in neutrophils; therefore, we sought to characterize its localization and function as it relates to PMN apoptosis. We found that Mcl-1 localized to the nucleus… CONTINUE READING

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