The longitudinal relation between brain lesion load and atrophy in multiple sclerosis: a 14 year follow up study.

@article{Chard2003TheLR,
  title={The longitudinal relation between brain lesion load and atrophy in multiple sclerosis: a 14 year follow up study.},
  author={D T Chard and Peter A. Brex and Olga Ciccarelli and Colette M B Griffin and Geoffrey J. M. Parker and Catherine Dalton and Daniel R. Altmann and Alan J. Thompson and David H. Miller},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={2003},
  volume={74 11},
  pages={1551-4}
}
BACKGROUND Studies have suggested that T2 lesion activity is prominent in early relapsing-remitting multiple sclerosis, whereas brain atrophy, while seen early, appears more evident in later progressive disease. The temporal relation between these processes remains unclear. OBJECTIVE To explore the association between changing brain lesion loads and subsequent tissue atrophy in multiple sclerosis. METHODS 28 subjects with clinically probable or definite multiple sclerosis (mean age 46.0… CONTINUE READING