The long-term retention of platinum in human tissues following the administration of cisplatin or carboplatin for cancer chemotherapy.

Abstract

Mass spectrometry has been used to study the distribution and retention of platinum in the tissues of patients following the administration of cisplatin or carboplatin. Blood platinum was measured up to 2 years and renal excretion up to 5 years after treatment. Platinum concentrations in plasma and red cells fell according to a power function, approximately… (More)

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