The long term prognostic significance of c-erbB-2 in primary breast cancer.

@article{Winstanley1991TheLT,
  title={The long term prognostic significance of c-erbB-2 in primary breast cancer.},
  author={John Winstanley and T M Cooke and Gordon D. Murray and Angela M. Platt-Higgins and William D George and Stacey Holt and M. Myskov and Anne V Spedding and Bruce Barraclough and Philip Spencer Rudland},
  journal={British Journal of Cancer},
  year={1991},
  volume={63},
  pages={447 - 450}
}
The expression of the c-erbB-2 oncogene has been evaluated using an immunohistochemical technique with the 21N polyclonal antibody in paraffin embedded tissue from 465 patients treated between the years 1975-1981 for Stage I and II breast cancer. One hundred and four (22%) patients exhibited positive staining. This was not associated with any other variables. Expression of the oncogene was associated with significantly poorer survival which was independent of other tumour variables. 

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