The long-term effects of cocaine use on cognitive functioning: A systematic critical review

  title={The long-term effects of cocaine use on cognitive functioning: A systematic critical review},
  author={Kirsten M Frazer and Qwynten Richards and Diana R Keith},
  journal={Behavioural Brain Research},
Structural and functional signatures of executive deficits after early use of cocaine depend upon the route of administration
C cocaine routes of administration are associated to a differential profile that may not be due direct effects of stimulant action but also driven by cognitive and biological differences in key executive functioning and attention areas, which could inform clinical management and should be taken into account in clinical research.
Recent cocaine use and memory impairment in HIV
For individuals with HIV, cocaine use is associated with a temporary decline in verbal memory, is characterized by greater encoding deficits, and these effects may reduce with abstinence, according to toxicology analysis and conventional methods of evaluating memory profiles.
Learning functions in short-term cocaine users
Social and Non-Social Cognitive Enhancement in Cocaine Users—A Closer Look on Enhancement Motives for Cocaine Consumption
This study demonstrates that cocaine is partially instrumentalized by CU with specific enhancement motives to counteract related cognitive impairments.
Specific Aspects of Executive Functioning Impacted in HIV and Cocaine Dependence
Background: Our study aimed to understand the effects of HIV and cocaine dependence (CD) on discrete aspects of executive functioning via the Stroop Color-Word Test and the Trail Making Test (TMT).
Neurocognitive and substance use disorders in older adults: challenges and evidence
This review highlights some of the intertwining aspects between substance use disorders and neurocognitive disorders in older adults and provides a comprehensive summary of the available evidence on treatment in this population.
Identifying cognitive deficits in cocaine dependence using standard tests and machine learning


Neurocognitive Deficits in Cocaine Users: A Quantitative Review of the Evidence
The results are consistent with findings from neuroimaging and neurochemical studies that have found cocaine use to be associated with dysfunctions in the anterior cingulate gyrus and orbitofrontal cortex; these regions are highly implicated in the mediation of attentional and executive functions, respectively.
Dose-related neurobehavioral effects of chronic cocaine use.
Chronic cocaine use is associated with persistent decrements in cognitive function that are most pronounced in heavy users, and knowledge of specific cognitive processing deficits in chronic cocaine users would be useful for designing individually tailored drug treatment programs.
Neuropsychological effects associated with recreational cocaine use
Findings are consistent with the emerging literature suggesting subtle cognitive deficits, putatively reflecting underlying dopaminergic dysfunction, in non-dependent, recreational cocaine users.
Cognitive dysfunctions in recreational and dependent cocaine users: role of attention-deficit hyperactivity disorder, craving and early age at onset
Cocaine use and ADHD seem to have mutually aggravating effects on cognitive impairment and cognitive deficits occur at a recreational and non-dependent level of cocaine use.
Chronic Cocaine Self-Administration in Rhesus Monkeys: Impact on Associative Learning, Cognitive Control, and Working Memory
The results suggest a combination of generalized, possibly attentional, impairments, along with a more specific cognitive control impairment implicating orbitofrontal cortex dysfunction in cocaine users.
Sex differences in neurocognitive functioning among abstinent recreational cocaine users
Data partially support the notion of sex-related neurocognitive variation in short-term abstinence from recreational cocaine use, but do not suggest that sex is a major factor.
Neuropsychological Assessment of Current and Past Crack Cocaine Users
Chronic crack cocaine use seems to disrupt general cognitive functioning (MMSE), verbal memory, and attentional resources, but findings suggest that some of these effects could be reversed by abstinence.
Take it or leave it: prefrontal control in recreational cocaine users
Functional magnetic resonance imaging analyses indicated that, compared with controls, stopping in the recreational users was associated with increased activation in the pre-supplementary motor area but not the right inferior frontal cortex, which implies intact response inhibition abilities in recreational cocaine users.