The long-term effect of cisplatin on renal function.

@article{Fjeldborg1986TheLE,
  title={The long-term effect of cisplatin on renal function.},
  author={P C Fjeldborg and Jb S{\o}rensen and P E Helkjaer},
  journal={Cancer},
  year={1986},
  volume={58 10},
  pages={
          2214-7
        }
}
The long-term effect of cisplatin on renal function was studied in a follow-up investigation, 16 to 52 months after chemotherapy in 22 patients with disseminated nonseminomatous testicular cancer. The median cumulated cisplatin dose was 452 mg/m2 (range, 275-650 mg/m2). Prehydration with isotonic saline secured diuresis above 100 ml/hour. GFR (glomerular filtration rate: 51Cr-EDTA clearance) fell by 12.5% (median, P less than 0.01) compared with the pretreatment level. Effective renal plasma… CONTINUE READING
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