The long-term course of rapid-cycling bipolar disorder.

@article{Coryell2003TheLC,
  title={The long-term course of rapid-cycling bipolar disorder.},
  author={William Coryell and David A. Solomon and Carolyn L. Turvey and Mart{\'i}n Keller and Andrew C. Leon and Jean Endicott and Pamela J. Schettler and Lewis L. Judd and Timothy I. Mueller},
  journal={Archives of general psychiatry},
  year={2003},
  volume={60 9},
  pages={
          914-20
        }
}
BACKGROUND Rapid cycling among patients with bipolar affective disorders is important because of its implications for long-term prognosis and for the use of antidepressants. To our knowledge, no prospective study has, as yet, described the course of this phenomenon beyond 5 years. METHODS From 345 patients with bipolar I or bipolar II disorder followed up for a mean (SD) of 13.7 (6.1) years as part of the National Institute of Mental Health Collaborative Depression Study, 89 (25.8%) were… CONTINUE READING
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