The long road to leptin.

  title={The long road to leptin.},
  author={J. Friedman},
  journal={The Journal of clinical investigation},
  volume={126 12},
Leptin is an adipose tissue hormone that functions as an afferent signal in a negative feedback loop that maintains homeostatic control of adipose tissue mass. This endocrine system thus serves a critical evolutionary function by protecting individuals from the risks associated with being too thin (starvation) or too obese (predation and temperature… CONTINUE READING