The long pentraxin PTX3 is crucial for tissue inflammation after intestinal ischemia and reperfusion in mice.

@article{Souza2009TheLP,
  title={The long pentraxin PTX3 is crucial for tissue inflammation after intestinal ischemia and reperfusion in mice.},
  author={Danielle G Souza and Flavio A Amaral and Caio Tavares Fagundes and Fernanda Matos Coelho and Rosa M E Arantes and Lirl{\^a}ndia P Sousa and Martin M. Matzuk and Cecilia Garlanda and Alberto Mantovani and Adriana Abalen Martins Dias and Mauro M Teixeira},
  journal={The American journal of pathology},
  year={2009},
  volume={174 4},
  pages={1309-18}
}
The pentraxin superfamily is a group of evolutionarily conserved proteins that play important roles in the immune system. The long pentraxin PTX3 protein was originally described as able to be induced by pro-inflammatory stimuli in a variety of cell types. In this study, we evaluated the phenotype of Ptx3(-/-) mice subjected to ischemia followed by reperfusion of the superior mesenteric artery. In reperfused wild-type mice, there was significant local and remote injury as demonstrated by… CONTINUE READING