The long non-coding RNA Paupar regulates the expression of both local and distal genes

@inproceedings{Vance2014TheLN,
  title={The long non-coding RNA Paupar regulates the expression of both local and distal genes},
  author={Keith W. Vance and Stephen N. Sansom and Sheena R Lee and Vladislava Chalei and Lesheng Kong and Sarah E. Cooper and Peter L Oliver and Chris P. Ponting},
  booktitle={The EMBO journal},
  year={2014}
}
Although some long noncoding RNAs (lncRNAs) have been shown to regulate gene expression in cis, it remains unclear whether lncRNAs can directly regulate transcription in trans by interacting with chromatin genome-wide independently of their sites of synthesis. Here, we describe the genomically local and more distal functions of Paupar, a vertebrate-conserved and central nervous system-expressed lncRNA transcribed from a locus upstream of the gene encoding the PAX6 transcription factor… CONTINUE READING

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