The long non-coding RNA LINC00152 is essential for cell cycle progression through mitosis in HeLa cells

  title={The long non-coding RNA LINC00152 is essential for cell cycle progression through mitosis in HeLa cells},
  author={Linda N{\"o}tzold and Lukas Frank and Minakshi Gandhi and Maria Polycarpou-Schwarz and Matthias Gross and Manuel Gunkel and Nina Beil and Holger Erfle and Nathalie Harder and Karl Rohr and Jakob Trendel and Jeroen Krijgsveld and Thomas Longerich and Peter Schirmacher and Michael Boutros and Sylvia Erhardt and Sven Diederichs},
  booktitle={Scientific Reports},
In recent years, long non-coding RNA (lncRNA) research has identified essential roles of these transcripts in virtually all physiological cellular processes including tumorigenesis, but their functions and molecular mechanisms are poorly understood. In this study, we performed a high-throughput siRNA screen targeting 638 lncRNAs deregulated in cancer entities to analyse their impact on cell division by using time-lapse microscopy. We identified 26 lncRNAs affecting cell morphology and cell… CONTINUE READING
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