The long non-coding RNA HOTAIR promotes the proliferation of serous ovarian cancer cells through the regulation of cell cycle arrest and apoptosis.

@article{Qiu2015TheLN,
  title={The long non-coding RNA HOTAIR promotes the proliferation of serous ovarian cancer cells through the regulation of cell cycle arrest and apoptosis.},
  author={Jun-jun Qiu and Yan Wang and Jing-Xin Ding and Hong-yan Jin and Gong Yang and K. Y. W. Hua},
  journal={Experimental cell research},
  year={2015},
  volume={333 2},
  pages={
          238-48
        }
}
HOX transcript antisense RNA (HOTAIR) is a well-known long non-coding RNA (lncRNA) whose dysregulation correlates with poor prognosis and malignant progression in many forms of cancer. Here, we investigate the expression pattern, clinical significance, and biological function of HOTAIR in serous ovarian cancer (SOC). Clinically, we found that HOTAIR levels were overexpressed in SOC tissues compared with normal controls and that HOTAIR overexpression was correlated with an advanced FIGO stage… CONTINUE READING
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