The long journey of salicylates in ulcerative colitis: The past and the future.

@article{Caprilli2009TheLJ,
  title={The long journey of salicylates in ulcerative colitis: The past and the future.},
  author={Renzo Caprilli and Monica Cesarini and Erika Angelucci and Giuseppe Frieri},
  journal={Journal of Crohn's & colitis},
  year={2009},
  volume={3 3},
  pages={149-56}
}
The advent of salicylates in the treatment of ulcerative colitis started in 1938 with the discovery of Salazopyrin by Nanna Svartz. This drug offered for the first time a therapeutic chance to patients with ulcerative colitis. In this paper we describe the fascinating history of Salazopyrin and salicylates from the first serendipitous observations to the last randomized clinical trials. Attention was paid to the pharmacokinetics and the mechanism of action of 5-aminosalicylates and, in… CONTINUE READING

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