The long intergenic non-protein coding RNA 707 promotes proliferation and metastasis of gastric cancer by interacting with mRNA stabilizing protein HuR.

  title={The long intergenic non-protein coding RNA 707 promotes proliferation and metastasis of gastric cancer by interacting with mRNA stabilizing protein HuR.},
  author={Min Xie and Tianshi Ma and Jiangyang Xue and Hong-wei Ma and Ming Sun and Zhihong Zhang and Minjuan Liu and Ying-hua Liu and songwen Ju and Zhaoxia Wang and Wei De},
  journal={Cancer letters},

Long non-coding RNA LINC00707 acts as a competing endogenous RNA to enhance cell proliferation in colorectal cancer.

The upregulation of LINC00707 expression was significantly associated with tumor size, stage and poor survival in patients with CRC and is associated with a shorter survival time in patientswith CRC.

Long non-coding RNA LINC01116 regulated miR-744-5p/SCN1B axis to exacerbate lung squamous cell carcinoma.

LINC01116 regulated miR-744-5p/SCN1B axis to exacerbate LUSC, providing a helpful theoretic basis for the exploration of L USC treatment.

LncRNA RP11-138J23.1 Contributes to Gastric Cancer Progression by Interacting With RNA-Binding Protein HuR

The essential role of RP11-138J23.1 in GC is highlighted, suggesting that RP11 -138J 23.1 might be a potent therapeutic target for patients with GC.

Long non-coding RNA DEPDC1-AS1 promotes proliferation and migration of human gastric cancer cells HGC-27 via the human antigen R–F11R pathway

In vitro and in vivo assays showed that DEPDC1-AS1 promoted HGC-27 cell proliferation and migration and is a potential biomarker for the early detection or prognosis of GC.

Silencing long intergenic non-coding RNA 00707 enhances cisplatin sensitivity in cisplatin-resistant non-small-cell lung cancer cells by sponging miR-145.

The aberrant expression of long non-coding RNAs is closely associated with drug resistance in multiple types of cancer. Long intergenic non-coding RNA 00707 (LINC00707) has previously been reported

Long Noncoding RNA LINC00707 Accelerates Tumorigenesis and Progression of Bladder Cancer via Targeting miR-145/CDCA3 Regulatory Loop

It is found that LINC00707 expressions were notably upregulated in BC samples and cells and were associated with T stage, grade, and shorter overall survival in BC patients.

The Long Intergenic Noncoding RNA 00707 Sponges MicroRNA-613 (miR-613) to Promote Proliferation and Invasion of Gliomas

The regulatory axis of LINC00707/miR-613 provides new insights into the mechanism and treatment of gliomas.

Long Non-coding RNA JHDM1D-AS1 Interacts with DHX15 Protein to Enhance Non-Small-Cell Lung Cancer Growth and Metastasis

LINC00668 cooperated with HuR dependent upregulation of PKN2 to facilitate gastric cancer metastasis

It is found that LINC00668 level was upregulated in GC tissue and cells and predicted poor prognosis and cooperated with HuR-dependent upregulation of PKN2 to facilitate gastric cancer metastasis, which may provide a potential novel insight for GC treatment.



Long non‐coding RNA GHET1 promotes gastric carcinoma cell proliferation by increasing c‐Myc mRNA stability

Findings indicate thatGHET1 plays a pivotal role in gastric carcinoma cell proliferation via increasing c‐Myc mRNA stability and expression, which suggests potential use of GHET1 for the prognosis and treatment of gastric cancer.

The long intergenic noncoding RNA UFC1, a target of MicroRNA 34a, interacts with the mRNA stabilizing protein HuR to increase levels of β-catenin in HCC cells.

The lincRNA-UFC1, a target of microRNA 34a, promotes proliferation and reduces apoptosis in HCC cells to promote growth of xenograft tumors in mice and is associated with tumor size, Barcelona Clinic Liver Cancer stage, and patient outcomes.

The Long Intergenic Noncoding RNA 00707 Promotes Lung Adenocarcinoma Cell Proliferation and Migration by Regulating Cdc42

LINC00707 is a noncoding oncogene that exerts important regulatory functions in LAD, suggesting its potential as a biomarker in the prognosis and treatment of LAD.

Long noncoding RNA GAPLINC regulates CD44-dependent cell invasiveness and associates with poor prognosis of gastric cancer.

Findings implicating a novel lncRNA in gastric cancer, termed GAPLINC (gastric adenocarcinoma predictive long intergenic noncoding RNA), are reported based on the use of global microarray and in situ hybridization (ISH) analyses to identify aberrantly expressed lnc RNA in human Gastric cancer specimens.

Long non-coding RNA MALAT1 promotes tumour growth and metastasis in colorectal cancer through binding to SFPQ and releasing oncogene PTBP2 from SFPQ/PTBP2 complex

It is found that overexpression of MALAT1 could promote cell proliferation and migration in vitro, and promote tumour growth and metastasis in nude mice, implying that MALat1 might be a potential predictor for tumour metastasis and prognosis.

Long noncoding RNA HOXA-AS2 promotes gastric cancer proliferation by epigenetically silencing P21/PLK3/DDIT3 expression

The data suggest that HOXA-AS2 could be an oncogene for GC partly through suppressing P21, PLK3, and DDIT3 expression, and may be served as a candidate prognostic biomarker and target for new therapies in human GC.

LncRNA GClnc1 Promotes Gastric Carcinogenesis and May Act as a Modular Scaffold of WDR5 and KAT2A Complexes to Specify the Histone Modification Pattern.

It is revealed that GClnc1 is an oncogenic lncRNA in human gastric cancer, which was upregulated and associated with tumorigenesis, tumor size, metastasis, and poor prognosis in Gastric cancer.

Up‐regulated long non‐coding RNA H19 contributes to proliferation of gastric cancer cells

Assayed the H19 expression level in gastric cancer tissues by real‐time PCR, and verified that H19 was associated with p53, and that this association resulted in partial p53 inactivation, suggesting an important role for H19 in the molecular etiology of gastriccancer and potential application of H 19 in Gastric cancer therapy.

LncRNA MT1JP functions as a ceRNA in regulating FBXW7 through competitively binding to miR-92a-3p in gastric cancer

MT1JP, a down-regulated lncRNA in GC, was associated with malignant tumor phenotypes and survival of GC, and it is suggested that MT1JP may act as a potential therapeutic target and prognosis biomarker for GC.

Decreased long noncoding RNA SPRY4-IT1 contributing to gastric cancer cell metastasis partly via affecting epithelial–mesenchymal transition

Low expression of SPRY4-IT1 is involved in progression and metastasis of gastric cancer and may represent a novel biomarker of poor prognosis in patients with Gastric cancer.