The long chain α-tocopherol metabolite α-13'-COOH and γ-tocotrienol induce P-glycoprotein expression and activity by activation of the pregnane X receptor in the intestinal cell line LS 180.

Abstract

SCOPE Members of the vitamin E family or their metabolites may induce the xenobiotic transporter P-glycoprotein (P-gp), which can limit the bioavailability of drugs and phytochemicals. This study aimed to investigate if α- and γ-tocopherol, α- and γ-tocotrienol, the long chain metabolite α-tocopherol-13'-COOH, the short chain metabolites α- and… (More)
DOI: 10.1002/mnfr.201600605

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@article{Podszun2017TheLC, title={The long chain α-tocopherol metabolite α-13'-COOH and γ-tocotrienol induce P-glycoprotein expression and activity by activation of the pregnane X receptor in the intestinal cell line LS 180.}, author={Maren C Podszun and Metta Jakobi and Marc Birringer and Johanna Weiss and Jan Frank}, journal={Molecular nutrition & food research}, year={2017}, volume={61 3} }