The long and winding road to optimal HbA1c measurement.

  title={The long and winding road to optimal HbA1c measurement.},
  author={R. Rainey Little and Curt L. Rohlfing},
  journal={Clinica chimica acta; international journal of clinical chemistry},
The importance of hemoglobin A1c (HbA1c) as an indicator of mean glycemia and risks for complications in patients with diabetes mellitus was established by the results of long-term clinical trials, most notably the Diabetes Control and Complications Trial (DCCT) and United Kingdom Prospective Diabetes Study (UKPDS), published in 1993 and 1998 respectively. However, clinical application of recommended HbA1c targets that were based on these studies was difficult due to lack of comparability of… CONTINUE READING