The long-acting integrase inhibitor GSK744 protects macaques from repeated intravaginal SHIV challenge

  title={The long-acting integrase inhibitor GSK744 protects macaques from repeated intravaginal SHIV challenge},
  author={Jessica Radzio and William R. Spreen and Yun Lan Yueh and James Mitchell and Leecresia T. Jenkins and Jos{\'e} Gerardo Garc{\'i}a-Lerma and Walid Heneine},
  journal={Science Translational Medicine},
Daily preexposure prophylaxis (PrEP) with Truvada is a proven HIV prevention strategy; however, its effectiveness is limited by low adherence. Antiretroviral drug formulations that require infrequent dosing may increase adherence and thus PrEP effectiveness. We investigated whether monthly injections of a long-acting formulation of the HIV integrase inhibitor GSK1265744 (GSK744 LA) prevented simian/human immunodeficiency virus (SHIV) infection by vaginal challenge in macaques. Female pigtail… CONTINUE READING
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