The lognormal distribution fits the decay profile of eukaryotic mRNA.

  title={The lognormal distribution fits the decay profile of eukaryotic mRNA.},
  author={STEVE S. Sommer and N. Adam Rin},
  journal={Biochemical and biophysical research communications},
  volume={90 1},
  • S. Sommer, N. A. Rin
  • Published 12 September 1979
  • Biology, Medicine
  • Biochemical and biophysical research communications
Abstract A general program was written which simulates radioactive labeling of RNA in vivo . The program was used to determine the effect that different distributions of half-lives would have on the composite decay curve observed in a pulse-chase experiment. Four biologically relevant points emerge: 1) The published, experimentally determined composite decay curves for eukaryotic mRNA are not compatible with a normal, uniform, or exponential distribution of decay times. 2) The experimental… Expand
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