The locus of tumor necrosis factor-alpha action in lung inflammation.

  title={The locus of tumor necrosis factor-alpha action in lung inflammation.},
  author={Stephen C H Smith and Shawn J. Skerrett and Emil Y. Chi and Mechthild Jonas and Ken Mohler and Christopher B Wilson},
  journal={American journal of respiratory cell and molecular biology},
  volume={19 6},
The pulmonary host response to infection and inflammation appears, at least in part, to be compartmentalized from the systemic host response. Tumor necrosis factor-alpha (TNF-alpha) has been implicated in lung inflammation and injury, but its site(s) of action has not been clearly defined. To investigate this, transgenic mice (surfactant apoprotein C promotor/soluble TNF receptor type II-Fc fusion protein ([SPCTNFRIIFc] mice) were generated in which TNF-alpha was selectively antagonized in the… CONTINUE READING


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