The locus coeruleus as a site for integrating corticotropin-releasing factor and noradrenergic mediation of stress responses.

@article{Valentino1993TheLC,
  title={The locus coeruleus as a site for integrating corticotropin-releasing factor and noradrenergic mediation of stress responses.},
  author={Rita J Valentino and Stephen L. Foote and Michelle E. Page},
  journal={Annals of the New York Academy of Sciences},
  year={1993},
  volume={697},
  pages={173-88}
}
Anatomic and electrophysiologic studies have provided evidence that CRF meets some of the criteria as a neurotransmitter in the noradrenergic nucleus, the locus coeruleus (LC), although some of the criteria have yet to be satisfied. Thus, immunohistochemical findings suggest that CRF innervates the LC, but this must be confirmed at the ultrastructural level. CRF alters discharge activity of LC neurons and these effects are mimicked by some stressors. Moreover, the effects of hemodynamic stress… CONTINUE READING