The locus coeruleus–noradrenergic system: modulation of behavioral state and state-dependent cognitive processes

@article{Berridge2003TheLC,
  title={The locus coeruleus–noradrenergic system: modulation of behavioral state and state-dependent cognitive processes},
  author={Craig W. Berridge and Barry D. Waterhouse},
  journal={Brain Research Reviews},
  year={2003},
  volume={42},
  pages={33-84}
}
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Evidence for a specialized role of the locus coeruleus noradrenergic system in cortical circuitries and behavioral operations
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    Brain Research Reviews
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Heterogeneous organization of the locus coeruleus projections to prefrontal and motor cortices
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The consensus view of LC as a relatively homogeneous modulator of forebrain activity is challenged by demonstrating that neurons in the locus coeruleus maintain segregated connections to brain regions with distinctly different functions, and the impact of the system on the generation and maintenance of adaptive and maladaptive behaviors.
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The unique role that norepinephrine plays in prefrontal cortical and hippocampal function and how its interaction with its various receptors contribute to cognitive behaviors are summarized.
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The locus coeruleus and noradrenergic modulation of cognition
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  • 2009
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Elucidating the factors that control the activity of these neurons and the effect of noradrenaline in target regions is key to understanding how the brain allocates attention and apprehends the environment to select, store and retrieve information for generating adaptive behaviour.
The locus coeruleus-norepinephrine system and sensory signal processing: A historical review and current perspectives
Sex and the noradrenergic system.
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The goal of the proposed studies is to characterize the effects of noradrenergic (NA) afferents on cortical information processing and examine the relationship between the intensity of LC neuronal activity and rates of norepinephrine release in neocortex and hippocampus during manipulation of LC activity.
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