The locus coeruleus–noradrenergic system: modulation of behavioral state and state-dependent cognitive processes

@article{Berridge2003TheLC,
  title={The locus coeruleus–noradrenergic system: modulation of behavioral state and state-dependent cognitive processes},
  author={Craig W. Berridge and Barry D. Waterhouse},
  journal={Brain Research Reviews},
  year={2003},
  volume={42},
  pages={33-84}
}

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References

SHOWING 1-10 OF 1,024 REFERENCES
Extrathalamic modulation of cortical function.
TLDR
The goal of the proposed studies is to characterize the effects of noradrenergic (NA) afferents on cortical information processing and examine the relationship between the intensity of LC neuronal activity and rates of norepinephrine release in neocortex and hippocampus during manipulation of LC activity.
Noradrenergic mechanisms in stress and anxiety: I. preclinical studies
TLDR
These findings are relevant to an understanding of psychiatric disorders, such as panic disorder and post‐traumatic stress disorder (PTSD), the symptoms of which have been hypothesized to be related to alterations in noradrenergic function.
Enhancement of Behavioral and Electroencephalographic Indices of Waking following Stimulation of Noradrenergic β-Receptors within the Medial Septal Region of the Basal Forebrain
TLDR
The results suggest that the LC noradrenergic system exerts potent behavioral and EEG-activating effects via actions of norepinephrine at β-receptors located within MS.
...
1
2
3
4
5
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