The location of the ligand-binding site of carbohydrate-binding modules that have evolved from a common sequence is not conserved.

@article{Czjzek2001TheLO,
  title={The location of the ligand-binding site of carbohydrate-binding modules that have evolved from a common sequence is not conserved.},
  author={Mirjam Czjzek and David N. Bolam and Amor Mosbah and Julie Allouch and Carlos M G A Fontes and Lu{\'i}s M. A. Ferreira and Olivier Bornet and V{\'e}ronique Zamboni and Herv{\'e} Darbon and Nicola L D Smith and Gary W. Black and Bernard Henrissat and Harry J. Gilbert},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 51},
  pages={48580-7}
}
Polysaccharide-degrading enzymes are generally modular proteins that contain non-catalytic carbohydrate-binding modules (CBMs), which potentiate the activity of the catalytic module. CBMs have been grouped into sequence-based families, and three-dimensional structural data are available for half of these families. Clostridium thermocellum xylanase 11A is a modular enzyme that contains a CBM from family 6 (CBM6), for which no structural data are available. We have determined the crystal… CONTINUE READING

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