The location of splenic NKT cells favours their rapid activation by blood-borne antigen

@inproceedings{Barral2012TheLO,
  title={The location of splenic NKT cells favours their rapid activation by blood-borne antigen},
  author={Patricia Barral and Maria Dolores Sanchez-Ni{\~n}o and Nico van Rooijen and Vincenzo Cerundolo and Facundo D Batista},
  booktitle={The EMBO journal},
  year={2012}
}
Natural killer T (NKT) cells play an important role in mounting protective responses to blood-borne infections. However, though the spleen is the largest blood filter in the body, the distribution and dynamics of NKT cells within this organ are not well characterized. Here we show that the majority of NKT cells patrol around the marginal zone (MZ) and red pulp (RP) of the spleen. In response to lipid antigen, these NKT cells become arrested and rapidly produce cytokines, while the small… CONTINUE READING
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