The localization of the human myeloperoxidase gene is in close proximity to the translocation breakpoint in acute promyelocytic leukemia.

@article{Chang1987TheLO,
  title={The localization of the human myeloperoxidase gene is in close proximity to the translocation breakpoint in acute promyelocytic leukemia.},
  author={K S Chang and Wolfgang Dr. Schroeder and Michael J. Siciliano and Larry H. Thompson and K McCredie and Miloslav Beran and Emil J. Freireich and Jan C. Liang and Jos{\'e} Mar{\'i}a Guti{\'e}rrez Trujillo and Sanford A. Stass},
  journal={Leukemia},
  year={1987},
  volume={1 5},
  pages={
          458-62
        }
}
The human myeloperoxidase (MPO) gene has recently been cloned in our laboratory. Southern blot hybridization of our MPO cDNA to DNA from a somatic cell hybrid clone panel revealed that the MPO cosegregated with human chromosome 17. In situ hybridization mapped the MPO gene to chromosome 17q22-24. Although this location is close to the translocation breakpoint which occurs in acute promyelocytic leukemia (APL), t(15;17)(q22;q21-22), Southern blot hybridization with different restriction-digested… CONTINUE READING

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