The localization of [3H]-desipramine in central nerve terminals studied with electron microscope autoradiography and subcellular fractionation

@article{Yavin1979TheLO,
  title={The localization of [3H]-desipramine in central nerve terminals studied with electron microscope autoradiography and subcellular fractionation},
  author={Ziva Yavin and Anat Biegon and R F Hofstein and Denise Samuel},
  journal={Experientia},
  year={1979},
  volume={35},
  pages={1210-1212}
}
The cellular and subcellular distribution of [3H]-desipramine (DMI) in rat brain was studied by electron microscope (EM) autoradiography and by subcellular fractionation. A considerable proportion of label was found to be bound to the membranes of presynaptic nerve terminals, as well as to sites inside those terminals.