The localisation of inflammatory cells and expression of associated proteoglycans in response to implanted chitosan.

@article{Farrugia2014TheLO,
  title={The localisation of inflammatory cells and expression of associated proteoglycans in response to implanted chitosan.},
  author={B L Farrugia and John M Whitelock and Moonsun Jung and Barbara McGrath and Robert L. O'Grady and S. Joe McCarthy and Megan S. Lord},
  journal={Biomaterials},
  year={2014},
  volume={35 5},
  pages={1462-77}
}
Implantation of a foreign material almost certainly results in the formation of a fibrous capsule around the implant however, mechanistic events leading to its formation are largely unexplored. Mast cells are an inflammatory cell type known to play a role in the response to material implants, through the release of pro-inflammatory proteases and cytokines from their α-granules following activation. This study examined the in vivo and in vitro response of mast cells to chitosan, through… CONTINUE READING