The local differentiation of myelinated axons at nodes of Ranvier

@article{Poliak2003TheLD,
  title={The local differentiation of myelinated axons at nodes of Ranvier},
  author={S. Poliak and E. Peles},
  journal={Nature Reviews Neuroscience},
  year={2003},
  volume={4},
  pages={968-980}
}
  • S. Poliak, E. Peles
  • Published 2003
  • Biology, Medicine, Chemistry
  • Nature Reviews Neuroscience
  • Efficient and rapid propagation of action potentials in myelinated axons depends on the molecular specialization of the nodes of Ranvier. The nodal region is organized into several distinct domains, each of which contains a unique set of ion channels, cell-adhesion molecules and cytoplasmic adaptor proteins. Voltage-gated Na+ channels — which are concentrated at the nodes — are separated from K+ channels — which are clustered at the juxtaparanodal region — by a specialized axoglial contact that… CONTINUE READING
    582 Citations

    Paper Mentions

    Glial regulation of the axonal membrane at nodes of Ranvier
    • 68
    Molecular mechanisms of node of Ranvier formation.
    • 113
    Neuron-glia interactions at the node of Ranvier.
    • M. Rasband
    • Chemistry, Medicine
    • Results and problems in cell differentiation
    • 2006
    • 13
    The making of a node: a co-production of neurons and glia
    • 41
    Molecular domains of myelinated axons in the peripheral nervous system
    • 180
    • PDF
    Gliomedin Mediates Schwann Cell-Axon Interaction and the Molecular Assembly of the Nodes of Ranvier
    • 285
    • PDF
    Excitable domains of myelinated nerves: axon initial segments and nodes of Ranvier.
    • 39
    Spectrin and Ankyrin-Based Cytoskeletons at Polarized Domains in Myelinated Axons
    • 57
    • Highly Influenced

    References

    SHOWING 1-10 OF 205 REFERENCES
    Molecular dissection of the myelinated axon
    • 328
    Organizing Principles of the Axoglial Apparatus
    • 170
    Molecular domains of myelinated axons
    • 220
    • PDF
    On the molecular architecture of myelinated fibers
    • 279
    • PDF
    Paranodin, a Glycoprotein of Neuronal Paranodal Membranes
    • 211