The local differentiation of myelinated axons at nodes of Ranvier

  title={The local differentiation of myelinated axons at nodes of Ranvier},
  author={S. Poliak and E. Peles},
  journal={Nature Reviews Neuroscience},
  • S. Poliak, E. Peles
  • Published 2003
  • Biology, Medicine, Chemistry
  • Nature Reviews Neuroscience
  • Efficient and rapid propagation of action potentials in myelinated axons depends on the molecular specialization of the nodes of Ranvier. The nodal region is organized into several distinct domains, each of which contains a unique set of ion channels, cell-adhesion molecules and cytoplasmic adaptor proteins. Voltage-gated Na+ channels — which are concentrated at the nodes — are separated from K+ channels — which are clustered at the juxtaparanodal region — by a specialized axoglial contact that… CONTINUE READING
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