The loading rate determines tumor targeting properties of methotrexate-albumin conjugates in rats.

@article{Stehle1997TheLR,
  title={The loading rate determines tumor targeting properties of methotrexate-albumin conjugates in rats.},
  author={Gerd Stehle and Hannsj{\"o}rg Sinn and Andreas Wunder and H H Schrenk and S. Sch{\"u}tt and W Maier-borst and Dieter L. Heene},
  journal={Anti-cancer drugs},
  year={1997},
  volume={8 7},
  pages={
          677-85
        }
}
  • Gerd Stehle, Hannsjörg Sinn, +4 authors Dieter L. Heene
  • Published in Anti-cancer drugs 1997
  • Medicine
  • Albumin dominates the plasma proteins in man. Following our observation that albumin turnover in rodent tumors is markedly increased, we will present evidence that albumin can be employed as an efficient carrier for targeting cytostatic agents like methotrexate (MTX) into tumors. The considerable discrepancy in the molecular weight of MTX (454 Da) and albumin (about 67,000 Da) tempted researchers to load multiple drug molecules on one carrier molecule. It was supposed that the optimal… CONTINUE READING

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 36 CITATIONS

    Aufnahme von Albumin-Konjugaten in humane Tumor-Zelllinien

    VIEW 4 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Albumin binding ligands and albumin conjugate uptake by cancer cells

    • Eva Frei
    • Medicine
    • Diabetology & metabolic syndrome
    • 2011
    VIEW 3 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Functionalization of Iron Oxide Nanoparticles With HSA Protein for Thermal Therapy

    VIEW 1 EXCERPT
    CITES BACKGROUND