The liver as a stem cell and lineage system.

  title={The liver as a stem cell and lineage system.},
  author={Samuel H. Sigal and Shlomo Brill and A. S. Fiorino and Lola C. M. Reid},
  journal={The American journal of physiology},
  volume={263 2 Pt 1},
We propose that the liver is a stem cell and lineage system with many parallels to lineages in the bone marrow, gut, and epidermis, varying from them only in kinetics. All are organized with three compartments: a slow cycling stem cell compartment with cells expressing a fetal phenotype and responding slowly to injury; an amplification compartment with cells of intermediate phenotype rapidly proliferating in response to regenerative stimuli or acute injuries; and a terminal differentiation… CONTINUE READING


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