The liver as a lymphoid organ.

@article{Crispe2009TheLA,
  title={The liver as a lymphoid organ.},
  author={Ian Nicholas Crispe},
  journal={Annual review of immunology},
  year={2009},
  volume={27},
  pages={147-63}
}
The liver receives blood from both the systemic circulation and the intestine, and in distinctive, thin-walled sinusoids this mixture passes over a large macrophage population, termed Kupffer cells. The exposure of liver cells to antigens, and to microbial products derived from the intestinal bacteria, has resulted in a distinctive local immune environment. Innate lymphocytes, including both natural killer cells and natural killer T cells, are unusually abundant in the liver. Multiple… CONTINUE READING
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