The liver X receptors and sterol regulatory element binding proteins alter progesterone secretion and are regulated by human chorionic gonadotropin in human luteinized granulosa cells

@article{Xu2018TheLX,
  title={The liver X receptors and sterol regulatory element binding proteins alter progesterone secretion and are regulated by human chorionic gonadotropin in human luteinized granulosa cells},
  author={Yafei Xu and Jos{\'e} J. Hern{\'a}ndez-Ledezma and Scot M. Hutchison and Randy Lloyd Bogan},
  journal={Molecular and Cellular Endocrinology},
  year={2018},
  volume={473},
  pages={124-135}
}
There is increased expression of liver x receptor (LXR) target genes and reduced low density lipoprotein receptor (LDLR) during spontaneous luteolysis in primates. The LXRs are nuclear receptors that increase cholesterol efflux by inducing transcription of their target genes. Transcription of LDLR is regulated by sterol regulatory element binding proteins (SREBPs). Human chorionic gonadotropin (hCG) prevents luteolysis and stimulates progesterone synthesis via protein kinase A (PKA). Thus, our… CONTINUE READING
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