The little elongation complex functions at initiation and elongation phases of snRNA gene transcription.

Abstract

The small nuclear RNA (snRNA) genes have been widely used as a model system for understanding transcriptional regulation due to the unique aspects of their promoter structure, selectivity for either RNA polymerase (Pol) II or III, and because of their unique mechanism of termination that is tightly linked with the promoter. Recently, we identified the little elongation complex (LEC) in Drosophila that is required for the expression of Pol II-transcribed snRNA genes. Here, using Drosophila and mammalian systems, we provide genetic and molecular evidence that LEC functions in at least two phases of snRNA transcription: an initiation step requiring the ICE1 subunit, and an elongation step requiring ELL.

DOI: 10.1016/j.molcel.2013.07.003

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@article{Hu2013TheLE, title={The little elongation complex functions at initiation and elongation phases of snRNA gene transcription.}, author={Deqing Hu and Edwin R Smith and Alexander S. Garruss and Nima Mohaghegh and Joseph M Varberg and Chengqi Lin and Jessica I Jackson and Xin Gao and Anita Saraf and Laurence Florens and Michael P Washburn and Joel C. Eissenberg and Ali Shilatifard}, journal={Molecular cell}, year={2013}, volume={51 4}, pages={493-505} }