The lipopolysaccharide structures of Salmonella enterica serovar Typhimurium and Neisseria gonorrhoeae determine the attachment of human mannose-binding lectin to intact organisms.

@article{DevyatyarovaJohnson2000TheLS,
  title={The lipopolysaccharide structures of Salmonella enterica serovar Typhimurium and Neisseria gonorrhoeae determine the attachment of human mannose-binding lectin to intact organisms.},
  author={M Devyatyarova-Johnson and Ian Rees and Brian D. Robertson and Malcolm W. Turner and Nigel Klein and Dominic L. Jack},
  journal={Infection and immunity},
  year={2000},
  volume={68 7},
  pages={3894-9}
}
Mannose-binding lectin (MBL) is an important component of the innate immune system. It binds to the arrays of sugars commonly presented by microorganisms and activates the complement system independently of antibody. Despite detailed knowledge of the stereochemical basis of MBL binding, relatively little is known about how bacterial surface structures influence binding of the lectin. Using flow cytometry, we have measured the binding of MBL to a range of mutants of Salmonella enterica serovar… CONTINUE READING
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