The lipopolysaccharide-activated innate immune response network of the horseshoe crab

@inproceedings{Kawabata2009TheLI,
  title={The lipopolysaccharide-activated innate immune response network of the horseshoe crab},
  author={Shun-ichiro Kawabata and Takumi Koshiba and Takatoshi Shibata},
  year={2009}
}
Primary stimulation of the horseshoe crab innate immune system by bacterial lipopolysaccharide (LPS) activates a network of responses to ensure host defense against invading pathogens. Granular hemocytes selectively respond to LPS via a G protein-dependent exocytic pathway that critically depends on the proteolytic activity of the LPS-responsive coagulation factor C. In response to stimulation by LPS, the hemocyte secretes transglutaminase (TGase) and several kinds of defense molecules, such as… CONTINUE READING

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