The lipophilicity, pharmacokinetics, and cellular uptake of different chemically-modified tetracyclines (CMTs).

@article{Liu2001TheLP,
  title={The lipophilicity, pharmacokinetics, and cellular uptake of different chemically-modified tetracyclines (CMTs).},
  author={Yu Liu and Nungavarum S Ramamurthy and J{\'a}n Mare{\vc}ek and Hsi Ming Lee and Jian Long Chen and Maria Emanuel Ryan and Barry R. Rifkin and Lorne M. Golub},
  journal={Current medicinal chemistry},
  year={2001},
  volume={8 3},
  pages={
          243-52
        }
}
CMTs are analogs of tetracyclines, which are chemically modified to eliminate their antimicrobial efficacy but which retain their inhibitory activity against matrix metalloproteinases. These compounds have been found to inhibit connective tissue breakdown in animal models of diseases such as periodontitis, arthritis and cancer. Because CMTs exhibit different in vivo efficacy in these various models of disease, the current study compared their pharmacokinetics and other properties as follows… CONTINUE READING