The lipophilic extract of Hypericum perforatum exerts significant cytotoxic activity against T24 and NBT-II urinary bladder tumor cells.

@article{Skalkos2005TheLE,
  title={The lipophilic extract of Hypericum perforatum exerts significant cytotoxic activity against T24 and NBT-II urinary bladder tumor cells.},
  author={Dimitris C Skalkos and Nikolaos Efthimios Stavropoulos and Ioannis Tsimaris and Eleni M Gioti and Constantine D Stalikas and Unyime O. Nseyo and Elli E. Ioachim and Niki John Agnantis},
  journal={Planta medica},
  year={2005},
  volume={71 11},
  pages={1030-5}
}
Hypericum perforatum L. (St. John's wort) is a medicinal plant used for many pathologies, especially for the treatment of mild to moderate depression. In the present study we have investigated the cytotoxic activity of the locally collected (Epirus region) Hypericum perforatum L. against cultured T24 and NBT-II bladder cancer cell lines. The lipophilic extract of the herb, prepared using petroleum ether, induced apoptosis displaying LC(50) values at concentrations as low as 4 and 5 microg/mL. A… CONTINUE READING

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