The lipopeptide antibiotic A54145 biosynthetic gene cluster from Streptomyces fradiae

  title={The lipopeptide antibiotic A54145 biosynthetic gene cluster from Streptomyces fradiae},
  author={Vivian P. W. Miao and Ren{\'e}e L. Brost and Joanne P Chapple and Kevin Kin-Kwan She and Marie-François Co{\"e}ffet-Le Gal and Richard H. Baltz},
  journal={Journal of Industrial Microbiology and Biotechnology},
Ca2+-dependent cyclic lipodepsipeptides are an emerging class of antibiotics for the treatment of infections caused by Gram-positive pathogens. These compounds are synthesized by nonribosomal peptide synthetase (NRPS) complexes encoded by large gene clusters. The gene cluster encoding biosynthetic pathway enzymes for the Streptomyces fradiae A54145 NRP was cloned from a cosmid library and characterized. Four NRPS-encoding genes, responsible for subunits of the synthetase, as well as genes for… CONTINUE READING


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