The lipid peroxidation by-product 4-hydroxynonenal is toxic to axons and oligodendrocytes.

@article{McCracken2000TheLP,
  title={The lipid peroxidation by-product 4-hydroxynonenal is toxic to axons and oligodendrocytes.},
  author={Eileen McCracken and Valerio Valeriani and Catherine D Simpson and Teresa Jover and J Mcculloch and Deborah Dewar},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2000},
  volume={20 11},
  pages={1529-36}
}
Lipid peroxidation and the cytotoxic by-product 4-hydroxynonenal (4-HNE) have been implicated in neuronal perikaryal damage. This study sought to determine whether 4-HNE was involved in white matter damage in vivo and in vitro. Immunohistochemical studies detected an increase in cellular and axonal 4-HNE within the ischemic region in the rat after a 24-hour period of permanent middle cerebral artery occlusion. Exogenous 4-HNE (3.2 nmol) was stereotaxically injected into the subcortical white… CONTINUE READING