The lipid composition of autophagic vacuoles regulates expression of multilamellar bodies.

@article{Lajoie2005TheLC,
  title={The lipid composition of autophagic vacuoles regulates expression of multilamellar bodies.},
  author={Patrick Lajoie and Ginette Guay and J. W. Dennis and Ivan Robert Nabi},
  journal={Journal of cell science},
  year={2005},
  volume={118 Pt 9},
  pages={1991-2003}
}
Multilamellar bodies (MLBs) are responsible for surfactant secretion in type II alveolar cells but also accumulate in other cell types under pathological conditions, including cancer and lysosomal storage diseases such as Niemann-Pick C (NPC), a congenital disease where defective cholesterol transport leads to its accumulation in lysosomes. Mv1Lu type II alveolar cells transfected with Golgi beta1,6 N-acetylglucosaminyltransferase V (Mgat5), enhancing the polylactosamine content of complex-type… CONTINUE READING
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