The linker region of Smad2 mediates TGF-beta-dependent ERK2-induced collagen synthesis.

Abstract

Transforming growth factor (TGF)-beta1 can cause fibrosis diseases by enhancing production of collagen. However, the intracellular signaling mechanism for TGF-beta1 stimulation of this process has not been fully elucidated. The present study focused on this mechanism and the cross-talk between the MAPK and Smad pathways. Extracellular signal-regulated… (More)
DOI: 10.1016/j.bbrc.2009.05.084

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