The linker of the interferon response factor 3 transcription factor is not unfolded.

@article{Shukla2012TheLO,
  title={The linker of the interferon response factor 3 transcription factor is not unfolded.},
  author={Hem D Shukla and Paulius Vaitiekunas and A. K. Dutta Majumdar and Anatoly I. Dragan and Emilios Dimitriadis and Svetlana Kotova and Colyn Crane-Robinson and Peter L. Privalov},
  journal={Biochemistry},
  year={2012},
  volume={51 32},
  pages={6320-7}
}
Interferon response factor 3 (IRF-3) is a transcription factor that plays an essential role in controlling the synthesis of interferon-β (IFN-β) and is a protein consisting of two well-defined domains, the N-terminal DNA-binding and the C-terminal dimerization domains, connected by a 75-residue linker, supposedly unfolded. However, it was not clear whether in intact IRF-3 this linker segment of the chain, which carries the nuclear export signal and includes a region of high helical propensity… CONTINUE READING